The potential of activator protein 1 (AP-1) in cancer targeted therapy

Activator protein-1 (AP-1) is a transcription factor that consists of diverse group members including Jun, Fos, Maf, and ATF. AP-1 involves number processes such as proliferation, migration, invasion in cells. Dysfunctional activity associated with cancer initiation, development, invasion, migration drug resistance. Therefore, potential target for targeted therapy. Currently, some small molecule inhibitors targeting have been developed tested, showing anticancer effects. However, complex its structure function, different dimers may play roles type cancers. more research needed to reveal the specific mechanisms cancer, how select appropriate treatment strategies. Ultimately, this review summarizes combination therapy cancer.